A portal for protocols & tools
for HP C-13 pyruvate quantitative
image acquisition and processing


Our goal of this Co-Clinical Imaging Research Program (CIRP) (Project Number: 1U24CA253377) is to overcome the translational barrier, to develop co-clinical imaging research resources that will encourage a consensus on how quantitative imaging methods are optimized to improve the quality of imaging results for co-clinical trials. This will be accomplished by using novel quantitative metabolic preclinical hyperpolarized (HP) 13C magnetic resonance imaging (MRI) to assess therapeutic response of small cell neuroendocrine (SCNC) prostate cancer (PCa). Although this proposal will focus on current standard of care treatment, the new quantitative HP 13C metabolic MRI approaches developed in this proposal will have general applicability for a variety of new targeted therapeutic approaches being developed for SCNC as well as for the study of other diseases.

Website Resources 

This Co-Clinical Imaging Research Program website is a portal for quantitative HP 13C MRI protocols, data analyses tools, and correlative biology data which will provide a better understanding on how quantitative HP 13C MRI can be used in co-clinical imaging trials to improve the assessment of therapeutic response and resistance. While this project focuses on advanced prostate cancer, these new quantitative metabolic imaging techniques could ultimately benefit the clinical management of other cancers and diseases.

Upcoming Events

HMTRC 2023 Workshop

Dates: April 13-14th, 2023

The April 2023 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes lectures, hands-on training and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Pre-clinical HP Chemistry Preps, Human HP Investigational Dose Formulation & Production, Clinical Translation Methods, Clinical Trial Support, and Analysis & Display Software.

View 2023 Workshop Brochure

CIRP 2023 Annual Virtual Meeting

Dates: May 3rd-4th, 2023

Description: This meeting will focus on how quantitative imaging methods are optimized to improve the quality of imaging results for co-clinical trials of adult and pediatric cancers and what co-clinical quantitative imaging information is currently available at NCI co-clinical imaging research resources. The CIRP network was formed in 2018 based on a trans-NCI initiative, with joint effort of Cancer Imaging Program at Division of Cancer Treatment and Diagnosis, Division of Cancer Biology, and Division of Cancer Prevention. The mission is to advance the practice of precision medicine by establishing consensus-based best practices for co-clinical quantitative imaging to enable disease detection, risk stratification, and assessment/prediction of response to therapy. Seven of the nine CIRP teams will demonstrate their web-resources at this meeting. Previous CIRP annual meetings can be found at https://ncihub.org/groups/cirphub

Event and Registration Website

Call for Electronic Posters (Deadline March 22nd)

CIRP Member information